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For those participating in clinical trials of retatrutide, or for healthcare professionals seeking to understand the management of GLP-1-related nausea more broadly, several practical strategies are supported by clinical experience with similar licensed medicines

Reflux and gastroparesis considerations Because GLP-1 medications slow gastric emptying, they can worsen symptoms in some people who already have reflux, severe indigestion, or suspected gastroparesis

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By activating GLP-1 receptors in the brain, pancreas, and digestive tract, semaglutide reduces appetite, slows gastric emptying, and improves insulin sensitivity