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doi:10.3389/fcvm.2022.1000815 70

After 56 days, discard the pen even if medication remains, as sterility and potency cannot be guaranteed beyond this period

How Weight Loss Affects Nerves: Peripheral nerves are surrounded by fat Rapid fat loss changes nerve microenvironment Mechanical stress as tissues shrink around nerves Altered blood flow to nerves as vascular beds change Supporting Evidence: Higher doses (more weight loss) = more dysesthesia Doesn't occur early (takes time for substantial weight loss) Not seen with slower weight loss medications Theory 3: Metabolic Changes Retatrutide produces dramatic metabolic shifts: improved insulin sensitivity, altered lipid metabolism, changed glucose homeostasis

Hultgren, H