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[1] Retatrutide combines agonism at the GLP-1, GIP, and glucagon receptors, while Tirzepatide targets only the GLP-1 and GIP receptors

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Major weight loss, pain relief seen with Eli Lilly's next-gen drug in late-stage trial Retatrutide reduced knee pain by up to 75.8% in late-stage trial A new weight-loss drug that Eli Lilly is testing is helping patients in a late-stage trial lose an average of 28.7% of their body weight and offered "substantial" relief from osteoarthritis pain