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Co-formulation is a vendor convenience, not a pharmacological claim about additive effect
Although these assays were conducted in aqueous solution and must be interpreted with caution, as the protein environment can further modulate the redox potential of flavins, this combined evidence supports a mechanism in which roseoflavin-derived metabolites incorporate into FSP1 but cannot accept electrons from NAD(P)H, thereby inactivating the enzyme
In most studies, loading steps are used
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