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68 With a plethora of research for the mechanism of action of metformin, currently, the exact mechanism still stands controversial as the previous research studies conducted on preclinical models, in vitro and cell line models used a very high concentration (~milli-Moles) of metformin as compared to the therapeutic concentration (~micro-Moles) used in humans

In pharma, winning isnt always about having the best product on paper

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In the future, shotgun metagenomic sequencing and additional omics-data will aid in defining not only composition, but also the functional profile of bacteria