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Rather than raising NAD+ systemically (as NMN or NR supplementation does), NNMT inhibition preserves NAD+ specifically in the tissue where metabolic dysfunction is most pronounced a precision approach that appeals to researchers studying tissue-specific metabolic regulation

J Cell Physiol 2007

Surprisingly, compared with the CM from the vector adipocytes, CM from the CPT2KD adipocytes remarkably upregulated the mRNA expression of pro-inflammatory macrophage markers in BMDMs, whereas CM from the SIRT3OE-CPT2KD adipocytes partially reversed these changes (Fig

This effect is particularly important for individuals with obesity, as sustained weight loss is a key factor in mitigating the risks associated with excessive weight, such as cardiovascular disease, type 2 diabetes, and metabolic syndrome