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However, most CEAs of GLP-1RA versus insulin therapy for T2D patients have been model-based (e.g., Markov modeling simulation) analyses that used data mainly derived from clinical trials that assessed short-term drug efficacy in terms of biomarker changes among highly selective and homogenous patient populations [9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28]