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(3) Inhibiting Adipose Tissue Inflammation and Improving the Adipose Microenvironment In obesity, adipose tissue develops chronic lowgrade inflammation with abundant release of proinflammatory factors (such as TNF and IL6), disrupting the adipose microenvironment, further worsening fat metabolic abnormalities and insulin resistance, and forming a vicious cycle

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MOTS-C (Mitochondrial Open-Reading-Frame of the 12S rRNA-C) is a mitochondrial-derived peptide that plays a crucial role in metabolic regulation