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Patients with T2DM initiating GLP-1 RAs or metformin as first-line monotherapy were included (87,229 matched patients per cohort).The researchers found that compared with metformin, GLP-1 RA use was associated with a significantly lower risk for overall dementia, Alzheimer disease, and nonvascular dementias (adjusted hazard ratios, 0.90, 0.88, and 0.75, respectively)

The results from the phase III trials will inform regulatory decisions and potentially pave the way for MariTide to become licensed in the treatment of obesity and Type 2 diabetes