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at the intracellular level, uric acid is a compound that generates endothelial dysfunction by favoring the formation of cytokines and lipid peroxidation, reducing the amount of endothelial nitric oxide, and favoring the pro-inflammatory cascade ERK/p38 MAPK [25,26]

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Trends in the epidemiology of anxiety disorders from 1990 to 2021: a global, regional, and national analysis with a focus on the sociodemographic index

For example, 21.1 indicates that this was the first SBIR BAA/CSO in fiscal year 2021