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By separating the effects of magnesium supplementation from other confounding factors such as routine treatments using the repeated measures and nested model, it was clarified that magnesium supplementation had a significant effect on all migraine indicators

The development program ended after Phase II studies that failed on efficacy and, in the hip-fracture population, raised a cardiac safety concern

The modifications were as follows: the incubation time for the TE/Lysozyme treatment was reduced substantially from one hour to 15 minutes and the temperature for this step was increased from 37 C to 56 C