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Sustainable weight management is best achieved through a combination of dietary change, physical activity, and behavioural support, with pharmacotherapy used as an adjunct where clinically indicated and in line with NICE guidance

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To match the peak steady-state concentration, the loading dose can be calculated from equation (13): TARGET CONCENTRATION INTERVENTION: APPLICATION OF PHARMACOKINETICS & PHARMACODYNAMICS TO DOSE INDIVIDUALIZATION The basic principles outlined above can be applied to the interpretation of clinical drug concentration measurements on the basis of three major pharmacokinetic variables: absorption, clearance, and volume of distribution (and the derived variable, half-life)