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Animal studies indicate that serine may increase glutathione production by increasing the availability of cysteine while also reducing epigenetic changes associated with tumor development

84 The topical application of vasodilators provides pain relief in PDPN, suggesting a role for hypoxia and/or vascular dysfunction in the generation of neuropathic pain in DPN

This direct delivery method is particularly beneficial for individuals with conditions that affect nutrient absorption, such as Crohns disease or pernicious anemia