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[ Acknowledgements We thank Sven Paul, Institute of Animal Breeding and Husbandry, University of Kiel, for revising the manuscript, Matthias Leippe, Department of Zoophysiology, University of Kiel, for helpful information and Virbac for providing the picture "Internal organs of the horse"

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Particularly by modulating the denato-cerebello-thalamic pathway and the activities of the prefrontal, parietal, and temporal lobes, the striatum, and subthalamic nucleus [53], movement disorders such as essential tremor, ataxia, Parkinsons disease, and dystonia can be managed