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High levels of estrogen sulfate can be a risk factor for breast cancer

Lancet Respir Med 2015

The results show that in human skin explants, treatment with CG significantly reduces the percentage of cells with a high melanin content, which suggests a depigmentation effect, and that in explants irradiated with UVA/UVB, treatment with CG increases the levels of components of the dermal extracellular matrix, such as collagen type 1, elastin and sulfated GAGs, components that had decreased in irradiated explants

Additionally, somatostatin inhibits gastrointestinal activity, reducing pancreatic enzyme and gastric acid secretion, which indirectly decreases glucagon demand