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Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes

Several factors contribute, including: Lower estrogen affecting fat distribution and insulin sensitivity Age-related muscle loss reducing metabolic rate Increased cortisol responses during stress and poor sleep Greater blood sugar fluctuations leading to stronger cravings Slower digestion and decreased satiety signals after meals These changes create a situation where women can eat well, exercise, and still struggle with weight gain or stalled progress

Understanding how dietary choices interact with GLP-1 therapy helps patients maximize treatment benefits and tolerability