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They exhibited increased intraocular pressure and mydriasis, degeneration of retinal ganglion cells, optic nerve head excavation and reduction in optic nerve thickness, generalized severe irregularity of retinal vessels, faint presentation of choroidal vessels, and severe optic nerve disc atrophy
combination data is nonexistent Safety first Overlapping side effect profiles create legitimate concerns about additive adverse events Patience pays Phase 3 trials for both compounds are ongoing
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