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GSK3 serves as a key kinase in the hyperphosphorylation of the microtubule-associated protein tau, thereby contributing to neuronal dysfunction and degeneration [91, 92]
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G protein-coupled receptors (GPCRs) represent a prevalent area of research in the pharmaceutical sciences, with these receptors activating diverse signaling pathways in response to various ligands and depending on the specific tissue type, as illustrated by the following examples: When targeting G-protein-coupled receptors (GPCRs), alternative pathways such as fatty acid -oxidation (FAO) and other alternative pathways of glutamine metabolism provide nutrient support to cancer cells
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