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However, this increase in demand has had a notable impact on overall pharmacy spending, making it essential for employers to pay attention to how these drugs affect their health care costs

Polymorphisms of GCLM are associated with a decrease in GCLC expression in hemolytic anemia patients [80], both a decrease in GSH levels and a subsequent onset of drug resistance in cancer cell lines [81], and both reduced GCL activity and correspondingly decreased GSH levels in schizophrenia patients [82,83]

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