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We propose that the effects of cumulative loss of surface receptor with fast-internalizing, slow-recycling, lysosome-targeting agonists, along with increases in -arrestin-induced desensitization, become more apparent with time, eventually overriding any positive effects associated with noncanonical signaling

Smooth muscle function recovery was also reviewed [3,4] (i.e., sphincter dysfunction (pupil [86], lower esophageal and pyloric sphincter [92,93,94,95,96,97,98,99], urethral sphincter [100,101,102], intestinal adaptation, and lesion recovery [103,104])

ALC has also been reported to exert cholinomimetic effects and to modulate the gamma-amino butyric acid (GABA) system

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