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Figure 3 5 Strategies for osteoporosis management: gutbone axis targeted 5.1 FMT, probiotics, and prebiotics 5.1.1 FMT As a novel technique of organ transplantation, FMT involves transferring fecal microbiota from healthy donors to recipients to modify disturbed intestinal ecology, whose efficacy in treating digestive diseases such as Clostridioides difficile infection (CDI) (119), ulcerative colitis (120), and IBS (121) has been repeatedly verified