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J Am Soc Nephrol 2004;15:407-10

When an individual is exposed to high levels of xenobiotics, more glutathione is utilized for conjugation

The Glutathione Peroxidase System The glutathione or glutathione peroxidase system consists of glutathione peroxidase (GPx) and glutathione reductase (GR)

HDV-induced IFN- signalling increases the resistance to oxidant-induced cell death and reduces functions specific for differentiated hepatocytes Based on the finding that GSH levels were induced by HDV/IFN, and ATF4 being a stress response factor, we explored whether ATF4 induction had phenotypic effects, such as protection from stress stimuli and in particular, oxidative stress