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J Basic Appl Zool 83(1):117 Arabac Tamer S, Akbulut S, Erdoan , evik , Ercan FYeen B (2023) Neuropeptide W Exhibits Preventive and Therapeutic Effects on Acetic Acid-Induced Colitis via Modulation of the Cyclooxygenase Enzyme System

found that LPS stimulation led to an approximately 30-fold accumulation of succinate in mouse bone marrow-derived macrophages (BMDMs), which in turn specifically promoted the transcription and expression of IL-1 by inhibiting prolyl hydroxylase (PHD) and stabilizing HIF-1 ( During macrophage metabolic reprogramming, amino acid metabolism does not operate independently, but is embedded within the overall metabolic network