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Alcohol is one of the biggest culpritseven moderate drinking can chip away at your liver's glutathione reserves over time

Cell Immunol 130:5208, PMID: 2208308 Yamauchi A, Bloom ET (1997) Control of cell cycle progression in human natural killer cells through redox regulation of expression and phosphorylation of retinoblastoma gene product protein

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Eisner MD, Anthonisen N, Coultas D, Kuenzli N, Perez-Padilla R, Postma D, Romieu I, Silverman EK, Balmes JR: An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease