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doi: 10.1111/apt.12149 121 ChenZYuRXiongYDuFZhuS

Genetic, physiologic, socioeconomic, and environmental factors contribute to obesity in children

However, as mentioned previously for vagal afferent regulation of food intake, recent work has failed to demonstrate an effect of food intake via direct gut peptide signaling on VAN-localized receptors

Weight loss through lifestyle interventions clearly improves metabolic factors associated with obesity as well as conditions coexisting with obesity, warranting its use as a first-line treatment