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The proportional reporting ratio (PRR) was introduced to compare the reports for a specific combination of drugs and adverse events to those for all other combinations

It has been described unfavorable cardiovascular effects probably related to the blockade of ischemic preconditioning mentioned before, an endogenous mechanism that protects the heart from ischemic injury associated with hypoglycemic episodes producing electrocardiographic abnormalities and arrhythmias (Marques et al

For instance, overdominance of the quadriceps relative to the hamstrings during high-impact activities can cause excessive anterior tibial translation, putting the ACL at greater risk

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