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doi: 10.3389/fmolb.2025.1639327 Received 07 June 2025 Accepted 04 July 2025 Published 22 July 2025 Volume 12 - 2025 Edited by Venkaiah Betapudi, United States Department of Health and Human Services, United States Reviewed by Anderson Oliveira Souza, Federal University of Mato Grosso, Brazil Raffaella Scanga, University of Calabria, Italy Danish Idrees, University of Iowa Healthcare, United States Rahul Patil, Augusta State University, United States Updates Copyright 2025 Seneff and Kyriakopoulos

248 Promising effects have also been reported from trials using combinations of saffron with other herbal extracts, including rhodiola and turmeric extracts

Early human and animal data suggest effects on sleep quality can be observed within the first week of administration

A 5mg vial is ideal for initial assay development, while a 15mg vial provides better economy for long-term wound healing models