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This statement from a study by Docking and Cook in 2015 summarizes this section well While increases in tendon thickness have previously been described as negative, the findings of this study suggest that tendon thickening might be the tendons method of adapting to pathology

The loss of YAP in breast cancer leads to increased tumor cell invasion, proliferation, resistance to chemotherapeutics, and protection against cell death, suggesting that YAP acts as a tumor suppressor [88]

Chronic stress raises cortisol, and elevated cortisol encourages the body to store fat around the belly

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia