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Anyway, at higher concentrations, like those deriving from a high-fat diet, primary and secondary BAs can reduce gut barrier integrity with their detergent properties, causing increased intestinal permeability and, thus, oxidative stress, DNA damage, and production of inflammatory cytokines, such as IL-6 and TNF-alpha, which promote inflammation and cause the inactivation of the FXR, thereby powering a pro-inflammatory state in the colon [25]
Epub 2008 May 1
GSTs and intracellular signalling pathways MAPEG and eicosanoid signalling Redox regulation (Protein S-glutathionylation) Oxidative stress protection 992 views 53 slides Ozone Depletion Ozone Depletion
The measurement is expressed as nmol/mg protein and presented as a fold change
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