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According to David Lassen, PharmD and Chief Clinical Officer at Prime, In the first year, its pretty conclusive that were not seeing any return from a total cost of care perspective

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(2) Mechanistic superiority: Dual inhibition of TBK1 and IKK in eWAT restores AMPK-Thr172 phosphorylation, enhancing mitochondrial biogenesis (via UCP1 upregulation), catecholamine sensitivity (via cAMP upregulation and cAMP-mediated -adrenergic signal transduction) [201, 202]