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Injection site options include: - Back of arm - Belly (stay more than 1-2 inches AWAY from belly button) - Fatty part of thigh Administer the Injection: Most patients feel more comfort pinching the injection site for this step

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When started, PI3K converts phosphatidylinositol 4,5-bisphosphate (PIP2) to phosphatidylinositol 3,4,5-trisphosphate (PIP3), which recruits Akt to the plasma membrane where it becomes started through phosphorylation