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Pyruvic acid accumulates in the blood and is subsequently converted to lactic acid, with the potential development of lactic acidosis

Consider supplementation in asymptomatic patients with risk factors (see Table 2: Patient Risk Factors Associated with Folate Deficiency below) consider supplementation

This is particularly relevant for plantar fasciitis, as the condition often involves inflammation at the calcaneal attachment point where the fascia connects to the heel bone