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Furthermore, in a randomized, double-blind, placebo-controlled study enrolling 70 patients with AD aged 6 to 12 years, the administration of melatonin (6 mg daily) demonstrated to improve SCORAD ( p = 0.007), objective SCORAD ( p = 0.001), serum total IgE levels ( p = 0.005) and Childrens Sleep Habits Questionnaire scores ( p = 0.006) at 6 weeks (40)

they target, bind to, and degrade disease-associated mRNAs, reducing the levels of proteins implicated in specific pathological conditions 6

Biomaterials science

This inhibition results in reduced expression of key osteogenic markers, such as alkaline phosphatase (ALP) and osteocalcin, which are essential for the proper differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs)