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The role of Nrf2 gene polymorphisms in the susceptibility of patients to vitiligo and in altering the clinical presentation of the disease is also suspected [30]

This combo shields cells from oxidative stress, which is why people link glutathione to brighter, healthier skin

The reduction of roGFP2(S 2 ) is therefore a good example for an enzyme using an alternative reaction pathway to overcome a kinetic challenge, and we hypothesize that other non-glutathione disulfide substrates with reactive proximal cysteinyl residues and rather negative redox potentials also require a ternary complex for their reduction