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Sustained elevations in interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and other pro-inflammatory cytokines have been observed in individuals diagnosed with major depressive disorder

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Figure 1 Oxidative Stress and Antioxidants There is compelling evidence that suggests that noise over-exposure leads to an imbalance between excess free radical build-up, especially reactive oxygen, and nitrogen species (ROS and NRS), and its removal from cells in the auditory receptor

Stripped of its master antioxidant, the mitochondrial membrane is left defenseless against the massive influx of free radicals generated by the immune system's inflammatory response