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While that concern is completely normal, in many cases the actual risk is much lower than people assume

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NNMT has been explored as a target in obesity, insulin resistance, and age-related metabolic decline, supporting the rationale for translational research into body composition and performance contexts (Kannt & Pfenninger, Frontiers in Physiology )

The tissue that was repaired doesn't 'un-heal.' However, the underlying condition that caused the injury (biomechanics, training load, systemic inflammation) still needs to be addressed to prevent recurrence