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The dual agonism approach was controversial at its introduction GIP receptor agonism in isolation was considered to have limited metabolic utility based on earlier research but Tirzepatide's clinical and preclinical data have firmly established the synergistic value of GIPR + GLP-1R co-activation

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Contrarily, phenoloxidase (PO) activity is necessary for melanotic encapsulation, which may take place with or without hemocyte support (40)

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