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What This Means Practically For patients with Type 2 diabetes, these findings have practical implications: First-line treatment recommendation: Major diabetes guidelines now recommend GLP-1 agonists as first-line treatment (alongside or instead of metformin) for patients with established cardiovascular disease

Instead of filling in your whole bottom lip with a lighter shade of lipstick, try blotting a minimal amount just in the centre this will accentuate your lip shape without emphasising how much fuller your bottom lip is than your top lip

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