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Gradual dose reduction over 4-8 weeks allows the body to readjust, and thyroid levels should be checked both during and after the taper, since weight stabilization changes levothyroxine requirements once again

In spite of the lower response in each measured parameters, the response-behavior of the immunological mediators and the glutahione antioxidant pathway was analogous like that in the before subgroup

Biological sex is increasingly recognized as a relevant determinant, as sex-specific differences in hormone profiles, immune function, gut microbiota composition and GLP-1 RA pharmacodynamics have been associated with differences in weight-loss outcomes and gastrointestinal tolerability (127)

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