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Because GSH may oxidize after collection and GSSG is typically much less abundant, sample handling can substantially alter the apparent balance

The FoxO transcription factor family plays a prominent role in muscle physiological regulation, especially the FoxO3a subtype, which plays a key role in muscle autophagy, metabolic regulation, and sarcopenia occurrence by regulating the expression of autophagy-related genes (such as LC3 and BNIP3) [48]

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