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Generally, methylcobalamin naturally occurs in animal-based food and cyanocobalamin is the most common form of vitamin B12 supplements that are in the chemically synthesized form

This proposition is based on the stable expression levels of MyoD and myogenin, which are considered to be pivotal markers of satellite cell proliferation and differentiation, respectively

VPS34 is a phosphatidylinositol 3-kinase (PI(3)K) that phosphorylates the 3 positions of phosphatidylinositol (PI), generating PI3-phosphate (PI3P) [31]

Using similar strategies for upstream positive regulators of GPX4, for example, upregulating SLC7A11 expression via gene therapy, can multi-targetedly enhance the cells overall antioxidant capacity and GSH supply, thereby indirectly supporting and enhancing GPX4 activity (Liao et al., 2024)