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Plasmid To construct p4xCRE-3xSRE-TATA-Luc2P, four tandem repeats of the cAMP-response element (5-AGCCTGACGTCAGAG-3) 42,43 , three tandem repeats of the serum-response element (5-AGGATGTCCATATTAGGACATCT-3) 44,45 derived from the human c- fos gene, and an adenovirus E1b TATA sequence (5-AGGGTATATAATG-3) 46,47 were subsequently inserted into a pGL4.11 vector (Promega, Madison, WI, USA)