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One small randomized controlled trial in 450 pregnant women in West Africa, without specified MTHFR genotype but at high risk for preeclampsia, found that supplementation with 15 mg of riboflavin daily was not effective in preventing the condition (29), but the study was likely underpowered to detect a significant effect

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References Mechanism of Action 1 The activity of GHK-Cu is thought to be multifaceted and includes: GHK-Cu has been associated with the upregulation of genes involved in tissue repair, anti-inflammatory signaling, and antioxidant defense, and the downregulation of genes linked to fibrosis and oxidative stress