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Collectively, this raises the notion that the observed differences here are perhaps related to long-term selenium intake, a micronutrient that has been speculated to play a role in konzo pathogenesis, due to its essential requirement for maintaining antioxidant machinery 18

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doi:10.1021/cr500131f

Effects of metformin on markers of oxidative stress and antioxidant reserve in patients with newly diagnosed type 2 diabetes: a randomized clinical trial