Their benefits come with a complex and often under appreciated constellation of adverse effects, some of which are expected, some emerging, and some still poorly understood. Conclusion: GLP-1 RAs exemplify a fundamental principle in contemporary medicine: with every advantage comes a potential drawback
Cancer Epidemiol Biomark Prev 9(12):12811286 Alberts D, Ranger-Moore J, Einspahr J, Saboda K, Bozzo P, Liu Y, Xu XC, Lotan R, Warneke J, Salasche S, Stratton S, Levine N, Goldman R, Islas M, Duckett L, Thompson D, Bartels P, Foote J (2004) Safety and efficacy of dose-intensive oral vitamin A in subjects with sun-damaged skin.[Erratum appears in Clin Cancer Res
Based on currently available evidence DPP-4 inhibitors show only a neutral effect on cardiovascular outcomes in patients with high risk or established CVD in diabetes
In contrast, when analyzing stroke outcomes, the effect was more pronounced with GLP-1 RAs, which provided the greatest contribution to the reduction of stroke events