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These are not minor differences

In general, the higher the EGRac, the less endogenous FAD is available, thus the poorer the blood riboflavin levels 22

As chronic inflammation and mitochondrial dysfunction can result in oxidative stress (54, 55, 56, 57) and our results show that human inflammatory PE placentas exhibit more oxidative DNA damage (Fig 1I and J), we next investigated whether LPS treatment leads to placental oxidative DNA damage in this model

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