The 1GP1 active site model was curated by identifying key amino acids that surround the active site known to have roles in catalysis and substrate or inhibitor binding (GLN140 (glutamine), ARG177 (arginine), SEC45 (selenocysteine) and ARG50 (arginine)), as no bound ligand was present [22, 33,34,35,36,37,38]
Innovative solutions such as prodrug strategies and targeted drug delivery systems can enhance drug stability and minimize systemic toxicity, maximizing the therapeutic potential of GST inhibitors
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Spatial and temporal variability in edaphic properties, microbial assemblages and microclimatic conditions reprogram transcriptional regulation, metabolic networks and phenotypic plasticity, often modifying responses inferred under controlled environments