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Experimental approaches include behavioral testing (Morris water maze, novel object recognition), electrophysiology (LTP recording), neurochemical analysis, imaging techniques (PET, MRI), and various neurotoxin or transgenic disease models

The OH depolymerizes GI mucin, inactivates pyruvate dehydrogenase, an essential mitochondrial enzyme, and damages mitochondrial RNA and DNA in the GI tract (113)

Age-related cognitive decline Normal aging is associated with mild cognitive impairments that are caused by various neuroanatomical changes, including alterations in brain receptors, myelin dystrophy, loss of dendritic spines, and changes in nerve transmission (146)

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