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Often seen, rarely recognized: mast cell activation diseasea guide to diagnosis and therapeutic options

We showed that inherent anxiety at baseline and elevated expression of the mineralocorticoid receptors (MR) in the hippocampus predisposes to a stress-induced suppression of expression of metabotropic glutamate receptors-2 (mGlu2, a key inhibitor of spontaneous glutamate release) with development of depressive-like behavior via epigenetic mechanisms of histone acetylation [20]

Taken together, the metabolic modifications associated with GLP-1RA treatment appear to have a favorable impact on CV systems, such as vascular function [19, 20], subsequently leading to anti-atherosclerotic effects in T2D patients

Radwan, R