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Drug assays For proteostasis drug treatments, we dissolved MG132 (Sigma-Aldrich C2211) and Spautin-1 (Sigma-Aldrich SML0440) in DMSO at 10 mM concentration and administered by placing 40 L of each solution over the bacterial food lawn

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Long-term exposure of mice to nucleoside analogues disrupts mitochondrial DNA maintenance in cortical neurons